海洛因依赖者与非依赖者静脉注射海洛因（二乙酰吗啡）后的瞳孔反应。
Pupil responses to intravenous heroin (diamorphine) in dependent and non-dependent humans.
作者信息
Tress K H, El-Sobky A A
出版信息
Br J Clin Pharmacol. 1979 Feb;7(2):213-7. doi: 10.1111/j.1365-2125.1979.tb00924.x.
Abstract
- Intravenous heroin was administered to volunteers, in doses of 2.5 and 5 mg to non-dependent subjects and does of 1/6, 1/3 and 1/2 of their prescribed daily does of opiates to dependent subjects, and pupillary responses measured before and three times during the 2 h after injection. 2. Tolerance to the miotic effects of heroin in the dependent subjects was demonstrated--larger doses of heroin were needed to produce the same pupil response in dependent subjects than in non-dependent subjects and the duration of action was shorter in the former group. 3. The effect of concurrent oral methadone medication on pupil response to heroin was demonstrated. Subjects prescribed both methadone and heroin showed smaller control pupil diameters and a reduced dose effect to heroin than did subjects prescribed heroin alone.
摘要
- 给志愿者静脉注射海洛因，非依赖者的剂量为2.5毫克和5毫克，依赖者的剂量为其规定每日鸦片制剂剂量的1/6、1/3和1/2，并在注射前及注射后2小时内分三次测量瞳孔反应。2. 已证实依赖者对海洛因的缩瞳作用产生了耐受性——与非依赖者相比，依赖者需要更大剂量的海洛因才能产生相同的瞳孔反应，且前一组的作用持续时间更短。3. 已证实同时口服美沙酮药物对瞳孔对海洛因反应的影响。同时开具美沙酮和海洛因处方的受试者与仅开具海洛因处方的受试者相比，其对照瞳孔直径更小，对海洛因的剂量效应降低。
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本文引用的文献
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Comparative effects of 20 mgm. of morphine sulfate on non-addicts and former morphine addicts.20毫克硫酸吗啡对非成瘾者和 former morphine addicts的比较效应。（注：“former morphine addicts”这里原英文有误，推测可能是“former morphine addicts”，意为“ former morphine addicts”）完整准确的句子应该是：20毫克硫酸吗啡对非成瘾者和 former morphine addicts的比较效应。
如果修正错误后完整翻译为：20毫克硫酸吗啡对非成瘾者和 former morphine addicts的比较效应。
如果修正错误后准确翻译为：20毫克硫酸吗啡对非成瘾者和前吗啡成瘾者的比较效应。
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Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment.
Clin Pharmacol Ther. 1975 Aug;18(2):180-90. doi: 10.1002/cpt1975182180.
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