McMurry M P, Connor W E, Cerqueira M T
Am J Clin Nutr. 1982 Apr;35(4):741-4. doi: 10.1093/ajcn/35.4.741.
Eight Tarahumara Indian men participated in a metabolic study to measure the responsiveness of their plasma cholesterol levels to dietary cholesterol. They were fed isocaloric cholesterol-free and high cholesterol diets containing 20% fat, 15% protein, and 65% carbohydrate calories. On admission to the study, the Tarahumaras had a low mean plasma cholesterol concentration (120 mg/dl), reflecting their habitual low cholesterol diet. After 3 wk of a cholesterol-free diet their cholesterol levels were 113 mg/dl. The men were then fed a high cholesterol diet (1000 mg/day) which increased the mean total plasma cholesterol to 147 mg/dl (p less than 0.01) and also increased the low-density lipoprotein cholesterol concentration. Tarahumaras, habituated to a low cholesterol diet after weaning, had the typical hypercholesterolemic response to a high cholesterol diet that has been previously observed in subjects whose lifelong diet was high in cholesterol content.
八名塔拉乌马拉印第安男性参与了一项代谢研究，以测量他们血浆胆固醇水平对膳食胆固醇的反应。他们食用了等热量的不含胆固醇和高胆固醇饮食，其中脂肪占20%、蛋白质占15%、碳水化合物热量占65%。在进入该研究时，塔拉乌马拉人的平均血浆胆固醇浓度较低（120毫克/分升），这反映了他们习惯的低胆固醇饮食。在食用不含胆固醇的饮食3周后，他们的胆固醇水平为113毫克/分升。然后这些男性食用高胆固醇饮食（每天1000毫克），这使平均总血浆胆固醇增加到147毫克/分升（p小于0.01），同时也增加了低密度脂蛋白胆固醇浓度。断奶后习惯了低胆固醇饮食的塔拉乌马拉人，对高胆固醇饮食有典型的高胆固醇血症反应，这与之前在终身饮食中胆固醇含量高的受试者中观察到的情况相同。
