Halbreich U, Zumoff B, Kream J, Fukushima D K
J Clin Endocrinol Metab. 1982 Jun;54(6):1262-4. doi: 10.1210/jcem-54-6-1262.
The 24-h mean plasma cortisol concentration was compared with the mean plasma cortisol concentrations during short subperiods of the day in 88 normal subjects and 223 patients with a very wide range of mean 24-h cortisol levels. The correlation between the 1300-1600 h mean plasma cortisol concentration and the mean 24-h plasma cortisol concentration was extremely high in all groups. Mean cortisol concentrations during this short subperiod powerfully discriminate cortisol hypersecretors (patients with Cushing's syndrome, anorexia nervosa, or prostate cancer) from normal controls. Hence, it is suggested that the mean or integrated 1300-1600 h plasma cortisol concentration can be used as a reliable afternoon cortisol test for the presence of hypercortisolism.
在88名正常受试者和223名24小时平均皮质醇水平范围非常广泛的患者中，将24小时平均血浆皮质醇浓度与一天中短时间段内的平均血浆皮质醇浓度进行了比较。在所有组中，1300 - 1600小时的平均血浆皮质醇浓度与24小时平均血浆皮质醇浓度之间的相关性极高。在这个短时间段内的平均皮质醇浓度能够有效地区分皮质醇分泌过多者（库欣综合征、神经性厌食症或前列腺癌患者）与正常对照组。因此，有人建议，1300 - 1600小时的平均或整合血浆皮质醇浓度可作为检测皮质醇增多症的可靠下午皮质醇检测指标。
