啮齿动物中的眼部醛脱氢酶。
Ocular aldehyde dehydrogenase in rodents.
作者信息
Messiha F S
出版信息
Neurotoxicology. 1981 Dec;2(4):703-9.
The presence of NAD-dependent ocular aldehyde dehydrogenase in rodents is reported. The enzyme is species and strain-dependent. Ocular ALDH possesses a significantly greater specific activity than that of the hepatic tissue of the species studied. d-Amphetamine non-competitively inhibited rat eye ALDH in vitro. Short-term administration of cyclobenzaprine, a tricyclic compound with muscle relaxant property, induced ocular aldehyde dehydrogenase. This is compared with lack of effect of certain CNS-stimulants, ethanol intake and of a monoamine oxidase inhibitor on endogenous ALDH in vivo.
据报道，啮齿动物体内存在NAD依赖性眼醛脱氢酶。该酶具有物种和品系依赖性。在所研究物种的眼醛脱氢酶中，其比活性显著高于肝脏组织。在体外，d-苯丙胺对大鼠眼醛脱氢酶有非竞争性抑制作用。具有肌肉松弛特性的三环化合物环苯扎林短期给药可诱导眼醛脱氢酶。将此与某些中枢神经系统兴奋剂、乙醇摄入及单胺氧化酶抑制剂对体内内源性醛脱氢酶无作用的情况进行比较。
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