Dennis J, Chalmers I
Br J Obstet Gynaecol. 1982 Jun;89(6):418-26. doi: 10.1111/j.1471-0528.1982.tb03630.x.
The most frequently cited objective of perinatal care is the prevention of mortality and morbidity; but there is no general agreement about the indices which should be used to assess the extent to which this broad objective is being achieved. As mortality and morbidity observed during the perinatal period may reflect pathological processes originating earlier in pregnancy, putative indices of perinatal care should ideally be evaluated in clinical experiments comparing different modes of practice. Also, because perinatal practice can affect mortality and morbidity in a reciprocal manner, it is important to define indices of both mortality and morbidity. Morbidity indices should preferably be based on neonatal clinical signs which are both unambiguous and strongly predictive of later morbidity. We propose that the frequency of neonatal seizures beginning within 48 h of birth should be considered as an index which may meet these criteria in respect of full-term babies.
围产期护理最常被提及的目标是预防死亡和发病；但对于应使用哪些指标来评估这一广泛目标的实现程度，尚无普遍共识。由于围产期观察到的死亡和发病情况可能反映了妊娠早期就已出现的病理过程，理想情况下，围产期护理的假定指标应在比较不同实践模式的临床试验中进行评估。此外，由于围产期实践可以以相互的方式影响死亡和发病情况，因此定义死亡率和发病率的指标都很重要。发病率指标最好基于明确无误且对后期发病有强烈预测性的新生儿临床体征。我们建议，出生后48小时内开始的新生儿惊厥频率应被视为一个可能符合足月婴儿这些标准的指标。
