福斯高林对上皮细胞中钠和氯转运的刺激作用。
Stimulation of sodium and of chloride transport in epithelia by forskolin.
作者信息
Cuthbert A W, Spayne J A
出版信息
Br J Pharmacol. 1982 May;76(1):33-5. doi: 10.1111/j.1476-5381.1982.tb09187.x.
Abstract
The diterpene, forskolin, is shown to produce a concentration-dependent, increase in short circuit current in two epithelial preparations, amphibian skin and rat colon. In the amphibian tissue the increase is sensitive to amiloride and due to an increase in electrogenic transepithelial sodium transport towards the serosal side. In the rat colon piretanide attenuated the forskolin effect, suggesting the terpene increases electrogenic transepithelial chloride transport towards the mucosal side. Half-maximal activation of both processes was achieved with concentration of 1-3 microM, similar to those required to activate half-maximally the catalytic subunit of adenylate cyclase.
摘要
二萜类化合物毛喉素在两种上皮组织——两栖类皮肤和大鼠结肠中，呈现出浓度依赖性地增加短路电流的现象。在两栖类组织中，这种增加对氨氯吡脒敏感，且是由于向浆膜侧的电生性跨上皮钠转运增加所致。在大鼠结肠中，吡咯他尼减弱了毛喉素的作用，提示该萜类化合物增加了向黏膜侧的电生性跨上皮氯转运。两种过程的半数最大激活浓度为1 - 3微摩尔，这与半数最大激活腺苷酸环化酶催化亚基所需的浓度相似。
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本文引用的文献
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Br J Pharmacol. 1982 Apr;75(4):587-98. doi: 10.1111/j.1476-5381.1982.tb09178.x.
2
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.二萜类化合物毛喉素对腺苷酸环化酶的激活作用并不需要鸟嘌呤核苷酸调节蛋白。
J Biol Chem. 1981 Oct 10;256(19):9799-801.
3
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.福斯高林：膜及完整细胞中独特的腺苷酸环化酶二萜激活剂。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3363-7. doi: 10.1073/pnas.78.6.3363.
4
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