Rampen F H
Eur J Cancer Clin Oncol. 1982 Jan;18(1):107-10. doi: 10.1016/0277-5379(82)90033-5.
From studying cell kinetic parameters it is demonstrated that both males and females with metastatic melanoma respond favourably to various chemotherapy schedules. Male patients have a shorter doubling time (DT) of pulmonary secondaries prior to chemotherapy compared to females, which seems to give them a less favorable starting point. Also, the DT of lung metastases of males after chemotherapy is less favourable than that of females. However, a significant difference in DT is noticed between measurements prior to and after the institution of chemotherapy in both sexes. It is concluded that the alleged sex differences in response to chemotherapy may be an artifact due to differences in tumor growth kinetics between males and females.
通过对细胞动力学参数的研究表明，患有转移性黑色素瘤的男性和女性对各种化疗方案均有良好反应。与女性相比，男性患者在化疗前肺部继发性肿瘤的倍增时间（DT）较短，这似乎使他们的起始点不太有利。此外，男性化疗后肺转移灶的DT比女性更不理想。然而，两性在化疗开始前后的测量中，DT存在显著差异。得出的结论是，所谓的化疗反应性别差异可能是由于男性和女性肿瘤生长动力学的差异而产生的假象。
