Yannopoulos K, Cohen C J, Deppe G, Gusberg S B
Diagn Gynecol Obstet. 1982 Summer;4(2):115-25.
The prophylactic Papanicolaou Test contributes in diagnosing dysplasias and carcinoma in situ of the uterine cervix with a realistic 100% cure. Surgery and radiotherapy improved considerably quantity and quality of life in stages 1 and 2 lesions. However, stages 3 and 4 have shown little improvement in results. Systemic treatment with chemotherapy offers hope for control. Most of the drugs are ineffective against squamous cell carcinoma of the cervix. Experimental and clinical trials with CIS-platinum (2) diamminedichloride (DDP) show effectiveness against cervical carcinoma. In an effort to individualize the treatment, a chemosensitivity testing (CST) is applied analogous to the radiosensitivity testing (RST). Basically, a control biopsy and posttest dose of DDP biopsies are studied to evaluate the response using objective morphological criteria. This safe, relatively simple, clinically applicable approach offers an objective dimension in selecting the patients and in monitoring the treatment. An important observation that gives this study an original authenticity is the fact that radiation and chemotherapy affects the cells in an identical way. This similar morphological reaction most probably means an analogous biological expression of cellular injury and necrosis of the neoplastic cells.
预防性巴氏试验有助于诊断子宫颈发育异常和原位癌，治愈率可达100%。手术和放疗在1期和2期病变中显著改善了患者的生存质量和数量。然而，3期和4期病变的治疗效果改善甚微。化疗的全身治疗为控制病情带来了希望。大多数药物对子宫颈鳞状细胞癌无效。顺铂（2）二氯二氨铂（DDP）的实验和临床试验显示对子宫颈癌有效。为了实现个体化治疗，类似于放射敏感性测试（RST），采用了化学敏感性测试（CST）。基本上，通过研究对照活检和DDP活检的测试后剂量，使用客观形态学标准来评估反应。这种安全、相对简单且临床适用的方法为选择患者和监测治疗提供了客观依据。这项研究具有独特真实性的一个重要观察结果是，放疗和化疗以相同方式影响细胞。这种相似的形态学反应很可能意味着肿瘤细胞的细胞损伤和坏死具有类似的生物学表现。
