Witman G, Cadman E, Kapp D, Wagner F
Med Hypotheses. 1982 Apr;8(4):335-41. doi: 10.1016/0306-9877(82)90025-1.
Standard chemotherapy for malignant gliomas has not generally been successful. Recent reports have suggested that cis-diammine-dichloroplatinum is preferentially accumulated into brain tumors compared to surrounding brain tissue. A patient who had failed radiation treatments and multiple other chemotherapeutic agents responded both clinically and radiographically to this new drug. This clinical observation, when combined with the tissue distribution of cis-diamminedichloroplatinum, would indicate that further evaluation of this new agent in the treatment of brain malignancies is warranted.
恶性胶质瘤的标准化疗总体上并不成功。最近的报告表明，顺二氯二氨铂相比于周围脑组织，能优先在脑肿瘤中蓄积。一名放疗及多种其他化疗药物治疗均失败的患者，对这种新药在临床和影像学上均有反应。这一临床观察结果，结合顺二氯二氨铂的组织分布情况，表明有必要对这种新药在脑恶性肿瘤治疗中的应用作进一步评估。
