人脑肿瘤克隆形成细胞检测的潜力与局限性
Potentials and limitations of a clonogenic cell assay for human brain tumors.
作者信息
Rosenblum M L, Dougherty D V, Deen D F, Wilson C B
出版信息
Cancer Treat Rep. 1981;65 Suppl 2:61-6.
PMID:7346148
Abstract
Single cells from biopsies of ten malignant gliomas were treated with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) in vitro, and tumor cell survival was compared to patient response to nitrosourea therapy. The limitations of the methods and their interpretations and future prospects for clonogenic cell analyses are discussed.
摘要
取自10例恶性胶质瘤活检组织的单细胞在体外接受了1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）处理，并且将肿瘤细胞存活率与患者对亚硝基脲疗法的反应进行了比较。文中讨论了这些方法及其解读的局限性以及克隆形成细胞分析的未来前景。
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