Frentz G, Møller U, Keiding N
Br J Dermatol. 1982 Jul;107(1):7-14. doi: 10.1111/j.1365-2133.1982.tb00283.x.
The effect of serial biopsy sampling on S- and G2 + M-fractions in lower abdominal skin from leg ulcer patients was studied by single-nuclei DNA flow cytometry. Significant differences in both measurements were found in four biopsies taken at equal intervals within 24 h, but not in four biopsies taken at noon on four consecutive days. The variation in S-fractions was closely related to the injury from previous biopsy sampling(s) while the G3 + M-fraction variation tended to follow the time of the day. The study indicated local as well as systemic effects from previous biopsy sampling.
通过单核DNA流式细胞术研究了系列活检取样对腿部溃疡患者下腹部皮肤中S期和G2+M期细胞比例的影响。在24小时内等间隔采集的4次活检样本中，这两项测量均发现了显著差异，但在连续4天中午采集的4次活检样本中未发现差异。S期细胞比例的变化与先前活检取样造成的损伤密切相关，而G2+M期细胞比例的变化则倾向于随一天中的时间而变化。该研究表明先前活检取样存在局部和全身效应。
