Fingerle H, Fischer G, Classen H G
Food Chem Toxicol. 1982 Jun;20(3):301-6. doi: 10.1016/s0278-6915(82)80296-2.
Groups of ten male and ten female Sprague-Dawley rats were exposed for 92 and 84 wk, respectively, to increasing concentrations of cadmium (as the chloride) in their drinking-water. The exposure levels of Cd used were 0, 5, 12.6 and 31.5 ppm Cd, and 5 ppm Cd plus certain trace metals. Blood pressure was measured in unanaesthetized animals at regular intervals (46 times in females, 49 times in males) by an indirect method to which the animals were kept conditioned. At the end of the experiments blood pressure was also determined directly under sodium pentobarbital anaesthesia. Although the weight of the kidneys, Cd residues and the severity of histological alterations in the kidneys increased in a dose-related manner, the blood pressure and pulse rate were not significantly affected in any of the experimental groups. There was a dose-dependent decrease in water consumption; all other parameters remained unaffected.
将十只雄性和十只雌性斯普拉格-道利大鼠分为几组，分别在92周和84周内，让它们饮用含镉（氯化镉）浓度逐渐增加的水。所用的镉暴露水平分别为0、5、12.6和31.5 ppm镉，以及5 ppm镉加某些痕量金属。通过间接方法定期（雌性46次，雄性49次）测量未麻醉动物的血压，动物已适应该方法。实验结束时，也在戊巴比妥钠麻醉下直接测定血压。尽管肾脏重量、镉残留量以及肾脏组织学改变的严重程度呈剂量依赖性增加，但任何实验组的血压和脉搏率均未受到显著影响。饮水量呈剂量依赖性减少；所有其他参数均未受影响。
