Shrieve D C, Harris J W
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):585-8. doi: 10.1016/0360-3016(82)90689-7.
EMT6/SF cells exposed to cis-dichlorodiammine Pt(II) (DDP) for 1 hr in the presence of 10 mM cysteamine (MEA) survived better than cells treated with DDP alone (DMF-3.1). MEA added to cultures after removal of DDP also protected, even when the two exposures were separated by as long as 4 hr. Protection by MEA was concentration dependent: no significant protection was observed below 1 mM and maximum protection required 5 mM. When cells were incubated with 10 mM MEA immediately after removal of DDP, survival increased as a function of the length of exposure to MEA, reaching a maximum at 2 hr.
在10 mM半胱胺（MEA）存在的情况下，EMT6/SF细胞暴露于顺二氯二氨合铂（II）（DDP）1小时后，其存活情况比单独用DDP处理的细胞更好（DMF - 3.1）。在去除DDP后添加到培养物中的MEA也具有保护作用，即使两次暴露间隔长达4小时。MEA的保护作用呈浓度依赖性：在1 mM以下未观察到明显的保护作用，最大保护作用需要5 mM。当在去除DDP后立即将细胞与10 mM MEA一起孵育时，存活率随暴露于MEA的时间长度而增加，在2小时时达到最大值。
