• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ro-07-0582的细胞毒性；热疗增强作用及半胱胺的保护作用

Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

作者信息

Hall E J, Astor M, Geard C, Biaglow J

出版信息

Br J Cancer. 1977 Jun;35(6):809-15. doi: 10.1038/bjc.1977.122.

DOI:10.1038/bjc.1977.122
PMID:871368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025538/
Abstract

The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.

摘要

Ro-07-0582对缺氧细胞所表现出的选择性细胞毒性强烈依赖于温度。自由基清除剂半胱胺可降低这种细胞毒性，这表明硝基自由基或亚硝基中间体参与了该药物的细胞杀伤过程。即使存活分数降至0.01，Ro-07-0582也不会诱导染色体畸变。

相似文献

1
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.Ro-07-0582的细胞毒性；热疗增强作用及半胱胺的保护作用
Br J Cancer. 1977 Jun;35(6):809-15. doi: 10.1038/bjc.1977.122.
2
Ro-07-0582 as a radiosensitizer and cytotoxic agent.
Int J Radiat Oncol Biol Phys. 1977 May-Jun;2(5-6):521-30. doi: 10.1016/0360-3016(77)90163-8.
3
In vivo assay of the radiation sensitivity of hypoxic tumour cells; influence of gamma-rays cyclotron neutrons, misonidazole, hyperthermia and mixed modalities.乏氧肿瘤细胞辐射敏感性的体内测定；γ射线、回旋加速器中子、米索硝唑、热疗及联合治疗方式的影响
Br J Cancer Suppl. 1978 Jun;3:194-7.
4
Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.放射增敏剂在多细胞球体中的细胞毒性：与热疗的联合治疗
Br J Cancer Suppl. 1978 Jun;3:168-72.
5
Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.热疗对缺氧细胞放射增敏剂Ro-07-0582体外对哺乳动物细胞的差异细胞毒性的影响。
Br J Cancer. 1977 Mar;35(3):307-13. doi: 10.1038/bjc.1977.44.
6
Hyperthermic potentiation of cytotoxicity of Ro-07-0582 in multicell spheroids.罗-07-0582在多细胞球体中细胞毒性的热增强作用。
Int J Radiat Oncol Biol Phys. 1977 May-Jun;2(5-6):531-5. doi: 10.1016/0360-3016(77)90164-x.
7
[Gene mutations, chromosome aberrations and survival after the x-ray irradiation of a Chinese hamster cell culture protected by cysteamine].[半胱胺保护的中国仓鼠细胞培养物经X射线照射后的基因突变、染色体畸变与存活情况]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1983(7):92-7.
8
Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.长时间暴露于米索硝唑后抗肿瘤药物细胞毒性增强。
Br J Cancer. 1981 Aug;44(2):201-7. doi: 10.1038/bjc.1981.171.
9
Combined radiation-protective and radiation-sensitizing agents: II. Radiosensitivity of hypoxic or aerobic Chinese hamster fibroblasts in the presence of cysteamine and misonidazole: implications for the "oxygen effect" (with appendix on calculation of dose-modifying factors).联合辐射防护剂与辐射增敏剂：II. 半胱胺和米索硝唑存在下缺氧或有氧中国仓鼠成纤维细胞的辐射敏感性：对“氧效应”的影响（附剂量修正因子计算附录）
Radiat Res. 1981 Aug;87(2):265-83.
10
Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells.指数生长的中国仓鼠细胞经巯基化合物进行热致敏作用
Cancer Res. 1979 Nov;39(11):4630-5.

引用本文的文献

1
Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro.巯基、抗坏血酸盐和氧作为米索硝唑体外毒性和代谢的调节剂。
Br J Cancer. 1980 Jun;41(6):892-900. doi: 10.1038/bjc.1980.166.
2
Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue.米索硝唑与热疗对C3H小鼠乳腺癌及其周围正常组织放射敏感性的影响。
Br J Cancer. 1980 Jan;41(1):10-21. doi: 10.1038/bjc.1980.2.
3
Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate.甲硝唑（灭滴灵）和米索硝唑（Ro-07-0582）的细胞毒性：乳酸的增强作用
Br J Cancer. 1981 Mar;43(3):350-4. doi: 10.1038/bjc.1981.55.
4
Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship.适度热疗增强放射增敏剂的细胞毒性：电子亲和力关系
Br J Cancer. 1982 Dec;46(6):912-7. doi: 10.1038/bjc.1982.301.
5
Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.硝基咪唑类药物与DNA的体外相互作用：构效关系
Br J Cancer. 1981 Nov;44(5):741-5. doi: 10.1038/bjc.1981.261.
6
Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.低浓度的米索硝唑可抵消极端缺氧对S期细胞的影响。
Br J Cancer. 1981 Mar;43(3):355-66. doi: 10.1038/bjc.1981.56.
7
Interaction of misonidazole and WR-2721--II. Modification of tumour radiosensitization.米索硝唑与WR-2721的相互作用——II. 肿瘤放射增敏作用的改变
Br J Cancer. 1983 Jan;47(1):65-72. doi: 10.1038/bjc.1983.8.
8
Interaction of radiosensitizers and WR-2721. I. Modification of skin radioprotection.放射增敏剂与WR-2721的相互作用。I. 皮肤辐射防护的改变
Br J Cancer. 1982 May;45(5):684-93. doi: 10.1038/bjc.1982.109.
9
Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.长时间暴露于米索硝唑后抗肿瘤药物细胞毒性增强。
Br J Cancer. 1981 Aug;44(2):201-7. doi: 10.1038/bjc.1981.171.
10
Enhancement of hyperthermochemotherapy for human gastric cancer in nude mice by thermosensitization with nitroimidazoles.用硝基咪唑类药物进行热致敏增强裸鼠人胃癌热化学疗法
Br J Cancer. 1988 Jul;58(1):42-5. doi: 10.1038/bjc.1988.158.

本文引用的文献

1
Pre-therapeutic experiments with the fast neutron beam from the Medical Research Council cyclotron. I. The biological and physical advantages and problems of neutron therapy.
Br J Radiol. 1963 Feb;36:77-80. doi: 10.1259/0007-1285-36-422-77.
2
The histological structure of some human lung cancers and the possible implications for radiotherapy.一些人类肺癌的组织学结构及其对放射治疗的可能影响。
Br J Cancer. 1955 Dec;9(4):539-49. doi: 10.1038/bjc.1955.55.
3
The gross response of an experimental tumour to single doses of x-rays.实验性肿瘤对单次X射线剂量的总体反应。
Br J Cancer. 1967 Mar;21(1):108-23. doi: 10.1038/bjc.1967.10.
4
The effect on cell survival of inhalation of oxygen under high pressure during irradiation in vivo of a solid mouse sarcoma.在对实体小鼠肉瘤进行体内照射期间高压吸入氧气对细胞存活的影响。
Br J Radiol. 1966 Jan;39(457):19-24. doi: 10.1259/0007-1285-39-457-19.
5
An estimation of changes in the proportions and absolute numbers of hypoxic cells after irradiation of transplanted C3H mousemammary tumours.移植的C3H小鼠乳腺肿瘤照射后低氧细胞比例和绝对数量变化的估计
Br J Radiol. 1969 Jun;42(498):441-7. doi: 10.1259/0007-1285-42-498-441.
6
Sensitization of anoxic mammalian cells to x-rays by triacetoneamine N-oxyl. Survival and toxicity studies.
Radiat Res. 1969 Jun;38(3):493-500.
7
Split-dose experiments with hypoxic cells. Implications for fractionated and low-dose-rate radiotherapy.
Radiology. 1974 Aug;112(2):425-30. doi: 10.1148/112.2.425.
8
Chemical radioprotection and radiosensitization of mammalian cells growing in vitro.体外培养的哺乳动物细胞的化学辐射防护与辐射增敏作用。
Radiat Res. 1973 Nov;56(2):291-306.
9
Metronidazole ('Flagyl'): mechanisms of radiosensitization.甲硝唑（“灭滴灵”）：放射增敏机制。
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Dec;26(6):557-69. doi: 10.1080/09553007414551591.
10
Selective chemotherapy of noncycling cells in an in vitro tumor model.体外肿瘤模型中非循环细胞的选择性化疗。
Cancer Res. 1974 Dec;34(12):3501-3.