Ro-07-0582的细胞毒性；热疗增强作用及半胱胺的保护作用
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
作者信息
Hall E J, Astor M, Geard C, Biaglow J
出版信息
Br J Cancer. 1977 Jun;35(6):809-15. doi: 10.1038/bjc.1977.122.
Abstract
The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.
摘要
Ro-07-0582对缺氧细胞所表现出的选择性细胞毒性强烈依赖于温度。自由基清除剂半胱胺可降低这种细胞毒性，这表明硝基自由基或亚硝基中间体参与了该药物的细胞杀伤过程。即使存活分数降至0.01，Ro-07-0582也不会诱导染色体畸变。
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本文引用的文献
1
Pre-therapeutic experiments with the fast neutron beam from the Medical Research Council cyclotron. I. The biological and physical advantages and problems of neutron therapy.
Br J Radiol. 1963 Feb;36:77-80. doi: 10.1259/0007-1285-36-422-77.
2
The histological structure of some human lung cancers and the possible implications for radiotherapy.
Br J Cancer. 1955 Dec;9(4):539-49. doi: 10.1038/bjc.1955.55.
3
The gross response of an experimental tumour to single doses of x-rays.
Br J Cancer. 1967 Mar;21(1):108-23. doi: 10.1038/bjc.1967.10.
4
The effect on cell survival of inhalation of oxygen under high pressure during irradiation in vivo of a solid mouse sarcoma.
Br J Radiol. 1966 Jan;39(457):19-24. doi: 10.1259/0007-1285-39-457-19.
5
An estimation of changes in the proportions and absolute numbers of hypoxic cells after irradiation of transplanted C3H mousemammary tumours.
Br J Radiol. 1969 Jun;42(498):441-7. doi: 10.1259/0007-1285-42-498-441.
6
Sensitization of anoxic mammalian cells to x-rays by triacetoneamine N-oxyl. Survival and toxicity studies.
Radiat Res. 1969 Jun;38(3):493-500.
7
Split-dose experiments with hypoxic cells. Implications for fractionated and low-dose-rate radiotherapy.
Radiology. 1974 Aug;112(2):425-30. doi: 10.1148/112.2.425.
8
Chemical radioprotection and radiosensitization of mammalian cells growing in vitro.
Radiat Res. 1973 Nov;56(2):291-306.
9
Metronidazole ('Flagyl'): mechanisms of radiosensitization.
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Dec;26(6):557-69. doi: 10.1080/09553007414551591.
10
Selective chemotherapy of noncycling cells in an in vitro tumor model.
Cancer Res. 1974 Dec;34(12):3501-3.
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