天然产物的高效液相色谱法（HPLC）Ⅴ. HPLC在无细胞生物合成中将α-氨基己二酰-半胱氨酰-缬氨酸（LLD）转化为异青霉素N中的应用 - Suppr | 超能文献

High performance liquid chromatography (HPLC) of natural products V. The use of HPLC in the cell-free biosynthetic conversion of alpha-aminoadipyl-cysteinyl-valine (LLD) into isopenicillin N.

作者信息

Neuss N, Berry D M, Kupka J, Demain A L, Queener S W, Duckworth D C, Huckstep L L

出版信息

J Antibiot (Tokyo). 1982 May;35(5):580-4. doi: 10.7164/antibiotics.35.580.

DOI:10.7164/antibiotics.35.580

Abstract

摘要

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High performance liquid chromatography (HPLC) of natural products V. The use of HPLC in the cell-free biosynthetic conversion of alpha-aminoadipyl-cysteinyl-valine (LLD) into isopenicillin N.天然产物的高效液相色谱法（HPLC）Ⅴ. HPLC在无细胞生物合成中将α-氨基己二酰-半胱氨酰-缬氨酸（LLD）转化为异青霉素N中的应用

J Antibiot (Tokyo). 1982 May;35(5):580-4. doi: 10.7164/antibiotics.35.580.

2

Cell-free conversion of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium.顶头孢霉中无细胞体系将δ-（L-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸转化为具有异青霉素N特性的抗生素。

Biochem J. 1979 Nov 15;184(2):427-30. doi: 10.1042/bj1840427.

3

Cell-free cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.将δ-（L-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸无细胞环化生成异青霉素N。

Antimicrob Agents Chemother. 1980 Sep;18(3):465-70. doi: 10.1128/AAC.18.3.465.

4

Incorporation of 3H from delta-(L-alpha-amino (4,5-3H)adipyl)-L-cysteinyl-D-(4,4-3H)valine into isopenicillin N.将δ-（L-α-氨基（4,5-³H）己二酰基）-L-半胱氨酰-D-（4,4-³H）缬氨酸中的³H掺入异青霉素N。

Biochem J. 1979 Nov 15;184(2):421-6. doi: 10.1042/bj1840421.

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Synthesis of delta-(alpha-aminoadipyl)cysteinylvaline and its role in penicillin biosynthesis.δ-（α-氨基己二酰）半胱氨酰缬氨酸的合成及其在青霉素生物合成中的作用。

Biochem J. 1976 Sep 1;157(3):651-60. doi: 10.1042/bj1570651.

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Penicillin biosynthesis: intermediates of biosynthesis of delta-L-alpha-aminoadipyl-L-cysteinyl-D-valine formed by ACV synthetase from Acremonium chrysogenum.青霉素生物合成：产黄青霉的ACV合成酶形成的δ-L-α-氨基己二酰-L-半胱氨酰-D-缬氨酸生物合成中间体。

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Enzymatic conversion of the unnatural tripeptide delta-(D-alpha-aminoadipyl)-L-cysteinyl-D-valine to beta-lactam antibiotics.非天然三肽δ-（D-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸向β-内酰胺抗生素的酶促转化

J Antibiot (Tokyo). 1984 Sep;37(9):1044-8. doi: 10.7164/antibiotics.37.1044.

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Stoichiometry of oxygen consumption in the biosynthesis of isopenicillin from a tripeptide.从三肽生物合成异青霉素过程中氧消耗的化学计量学

Biochem J. 1982 Jun 1;203(3):791-3. doi: 10.1042/bj2030791.

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Metabolic control analysis of the penicillin biosynthetic pathway: the influence of the LLD-ACV:bisACV ratio on the flux control.青霉素生物合成途径的代谢控制分析：LLD-ACV与双ACV比例对通量控制的影响

Antonie Van Leeuwenhoek. 1999 Jan-Feb;75(1-2):145-54. doi: 10.1023/a:1001781808150.

10

Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.产黄青霉的异青霉素N合成酶，一种将δ-（L-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸转化为异青霉素N的酶。

Antimicrob Agents Chemother. 1985 Mar;27(3):380-7. doi: 10.1128/AAC.27.3.380.

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Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis.cefD2的表达以及双组分差向异构酶系统将异青霉素N转化为青霉素N的过程是头孢菌素生物合成中的限速步骤。

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J Bacteriol. 1987 Apr;169(4):1611-8. doi: 10.1128/jb.169.4.1611-1618.1987.