Wile A G, Guilmette E, Friedberg H, Mason G R
J Surg Oncol. 1982 Sep;21(1):37-41. doi: 10.1002/jso.2930210110.
An animal model has been devised to investigate effects of hyperthermia and chemotherapeutic agents on normal and neoplastic tissue. This model uses the rabbit as the experimental animal and will permit the passage of the transplantable VX-2 carcinoma. The technique described parallels clinical isolation-perfusion and utilizes cis-platinum as the chemotherapeutic agent. This model has proven to be reliable and consistent in achieving tissue temperature at therapeutic ranges and has documented the safety of using cis-platinum in this mode of therapy.
已设计出一种动物模型，用于研究热疗和化疗药物对正常组织和肿瘤组织的影响。该模型以兔子作为实验动物，可使可移植的VX - 2癌通过。所描述的技术与临床隔离灌注相似，并使用顺铂作为化疗药物。该模型已证明在达到治疗范围内的组织温度方面是可靠且一致的，并且记录了在这种治疗方式中使用顺铂的安全性。
