Mann W, Jonas I, Riede U N, Beck C
Laryngol Rhinol Otol (Stuttg). 1981 Aug;60(8):426-30.
The connective tissue contains extracellular enzymes for the turnover of the ground substance. If this enzyme system gets out of control there is development of a complex metabolic disturbance of all tissue components. The lysosomal dysfunction is the basis of the general mechanism of tissue destruction in cholesteatoma, oto- and tympanosclerosis. This process seems most enhanced in cholesteatoma. Emphasis is placed on the role of extracellular lysosomes (= matrix vesicles).
结缔组织含有用于基质周转的细胞外酶。如果这个酶系统失去控制，所有组织成分就会出现复杂的代谢紊乱。溶酶体功能障碍是胆脂瘤、耳硬化症和鼓室硬化症中组织破坏一般机制的基础。这个过程在胆脂瘤中似乎最为明显。重点在于细胞外溶酶体（=基质小泡）的作用。
