基质小泡在鼓室硬化症发病机制中的作用。

The role of matrix vesicles in the pathogenesis of tympanosclerosis.

作者信息

Mann W, Riede U N, Jonas I, Beck C

出版信息

Acta Otolaryngol. 1980 Jan-Feb;89(1-2):43-52. doi: 10.3109/00016488009127107.

Abstract

In a histological and electron microscopical study the authors investigated the pathogenesis of tympanosclerosis. Emphasis was placed on the role of extracellular lysosomes (= matrix lysosomes). The function of such matrix lysosomes is connected with the two-stage degradation of the connective tissue. This system gets out of control in tympanosclerosis. Inflammatory and immunological processes are suggested to be superimposed on this lysosomal action.

摘要

在一项组织学和电子显微镜研究中，作者们调查了鼓室硬化症的发病机制。重点关注了细胞外溶酶体（即基质溶酶体）的作用。这种基质溶酶体的功能与结缔组织的两阶段降解有关。在鼓室硬化症中，这个系统失去了控制。炎症和免疫过程被认为叠加在这种溶酶体作用之上。