Ribeiro R C, Neves F A, Albuquerque R H, Dórea J G, Martinelli J G, da Costa e Silva A
Nephron. 1982;30(4):361-3. doi: 10.1159/000182518.
Two groups of adult male rats were used. One group was sham-operated, while the other group had about 70-80% of the left kidney tissue surgically excised and a total right nephrectomy performed 10 days later. Two 15-day mating periods were organized at the 10th and 18th week after surgery. Fertile and infertile rats of the uremic group showed low testosterone levels and increased zinc content of testes in comparison to sham-operated animals. These data contrast with previous reports that zinc deficiency may be a cause of low testosterone values and sexual dysfunction in uremic patients. It is concluded that zinc deficiency may not be involved in the pathogenesis of low testosterone levels and sexual dysfunction in uremic male rats.
使用了两组成年雄性大鼠。一组进行假手术，而另一组手术切除约70 - 80%的左肾组织，并在10天后进行右肾全切术。在术后第10周和第18周安排了两个为期15天的交配期。与假手术动物相比，尿毒症组的可育和不育大鼠睾酮水平较低，睾丸锌含量增加。这些数据与之前关于锌缺乏可能是尿毒症患者睾酮值低和性功能障碍原因的报道形成对比。得出的结论是，锌缺乏可能与尿毒症雄性大鼠睾酮水平低和性功能障碍的发病机制无关。
