Nagy P, Csaba I F, Szilágyi A
Z Geburtshilfe Perinatol. 1982 Apr-May;186(2):101-3.
The effects of methotrexate, actinomycin-D and cyclophosphamid on oxygen consumption, aerobic CO2-production and anaerobic glycolysis of human placentas from early pregnancy were studied on Warburg apparatus. All the mentioned cytostatic agents inhibited oxygen consumption. Aerobic CO2-production was increased by methotrexate and inhibited by actinomycin-D and cyclophosphamide, but blocking effect of the latter was only transitional. Anaerobic glycolysis was decreased continuously by actinomycin-D and cyclophosphamide, but methotrexate had decreasing effect only for a short time.
在瓦氏呼吸仪上研究了甲氨蝶呤、放线菌素-D和环磷酰胺对妊娠早期人胎盘氧消耗、有氧二氧化碳生成和无氧糖酵解的影响。所有上述细胞抑制剂均抑制氧消耗。甲氨蝶呤使有氧二氧化碳生成增加，放线菌素-D和环磷酰胺则使其受到抑制，但后者的阻断作用只是暂时的。放线菌素-D和环磷酰胺使无氧糖酵解持续减少，但甲氨蝶呤仅在短时间内有减少作用。
