Estrada-Flores E, Yáñez Mendoza C
Laboratorio de Histología y Embriología, Facultad de Ciencias, Universidad Nacional Autónoma de México, D.F.
Bol Estud Med Biol. 1990 Jul-Dec;38(3-4):59-64.
The placenta is a vascular organ within the uterus, connected to the fetus by the umbilical cord; it is the structure through which the fetus is nourished. In the rat placenta, three regions can be identified: the decidua basalis, the basal zone, and the labyrinth. In the present work, doses of 4.2 mg/kg of Natulán (Roche), as used for human therapy, were administered orally to pregnant rats. The number of glycogenic cells from the basal zone of the placenta was increased, which allows us to suggest that Natulán causes an inhibition of glycolysis, by blocking the metabolism of the placenta, as proposed by Warburg.
胎盘是子宫内的一个血管性器官，通过脐带与胎儿相连；它是胎儿获取营养的结构。在大鼠胎盘中，可以识别出三个区域：基蜕膜、基底区和迷路。在本研究中，将用于人类治疗的4.2毫克/千克剂量的纳图兰（罗氏公司生产）口服给予怀孕大鼠。胎盘基底区的糖原细胞数量增加，这使我们认为，正如瓦尔堡所提出的，纳图兰通过阻断胎盘的代谢而导致糖酵解受到抑制。
