[Cytoplasmic vacuoles and kinetics of bone marrow cells in alcoholism, liver cirrhosis and anemia].

Bone marrow smears show vacuoles in the cytoplasm of haematopoietic cells due to alcoholism, liver cirrhosis and anemias different origin, for example in acute leukemias, in proportion to the decreased content of haemoglobin. The cell doubling rat in vivo is not obviously impaired by the vacuolisation of the cytoplasm exactly as is the case with proliferation in vitro, although the vacuolation increases in vitro. Phase contrast observation makes visible the vacuoles without membranes and content as they appear transitorily in pinocytosis, and not as secondary lysosomes. The common cause for the formation of the vacuoles without membranes in the cytoplasm in all these pathological states could be intracellular hypoxia and acidosis.