Lelj F, Tancredi T, Temussi P A, Toniolo C
Farmaco Sci. 1980 Dec;35(12):988-96.
The analysis of the structure-activity relationship previously performed on the sweet L,L isomer of Asp-Phe-OMe was extended to the bitter L,D diastereoisomer. A combination of NMR measurements and of an original method of PEM calculations gives a description of the conformational state of the L,D isomer that can be effectively used to study the interaction with a previously proposed model of the bitter taste receptor site.
先前对天冬氨酰苯丙氨酸甲酯的甜味L,L异构体所进行的构效关系分析，扩展到了苦味的L,D非对映异构体。核磁共振测量与一种原始的PEM计算方法相结合，给出了L,D异构体构象状态的描述，该描述可有效地用于研究与先前提出的苦味受体位点模型的相互作用。
