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1
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引用本文的文献

1
Nutritional influences on metal toxicity: cadmium as a model toxic element.营养对金属毒性的影响：以镉作为典型毒性元素为例
Environ Health Perspect. 1979 Apr;29:95-104. doi: 10.1289/ehp.792995.
2
Effects of nutritional factors on metabolism of dietary cadmium at levels similar to those of man.营养因素对与人类摄入量相似水平的膳食镉代谢的影响。
Environ Health Perspect. 1979 Feb;28:107-14. doi: 10.1289/ehp.7928107.

本文引用的文献

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Human zinc deficiency, endocrine manifestations and response to treatment.人类锌缺乏、内分泌表现及对治疗的反应。
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Inorganic elements in weighed diets of girls and young women.女童和年轻女性称重饮食中的无机元素。
J Am Diet Assoc. 1969 Jul;55(1):38-43.
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Inorganic elements in foods used in hospital menus.医院菜单中所用食物中的无机元素。
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Biological availability in animals of iron from common dietary sources.
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Selenium: relation to decreased toxicity of methylmercury added to diets containing tuna.硒：与添加到含金枪鱼饮食中的甲基汞毒性降低的关系。
Science. 1972 Mar 10;175(4026):1122-4. doi: 10.1126/science.175.4026.1122.
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The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat.缺铁对大鼠摄入铅的组织含量及毒性的影响。
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Low levels of zinc in hair, anorexia, poor growth, and hypogeusia in children.儿童头发中锌含量低、厌食、生长发育不良和味觉减退。
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Dose-response to lead ingestion in rats fed low dietary calcium.低钙饮食喂养的大鼠对铅摄入的剂量反应。
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Zinc deficiency in man. The Shiraz experiment.人体锌缺乏。设拉子实验。
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Influence of dietary zinc on lead toxicity in the rat.膳食锌对大鼠铅毒性的影响。
J Nutr. 1976 May;106(5):689-96. doi: 10.1093/jn/106.5.689.

设计人类金属中毒动物模型时的营养考量

Nutritional considerations in designing animal models of metal toxicity in man.

作者信息

Fox M R

出版信息

Environ Health Perspect. 1978 Aug;25:137-40. doi: 10.1289/ehp.7825137.

DOI:10.1289/ehp.7825137
PMID:720300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1637179/
Abstract

In recent years, exposure of man to increasing amounts of metals has occurred rather generally from industrial contamination and variably from intake of dietary mineral supplements. Adverse effects of individual metals can be markedly altered by dietary levels of other essential and nonessential inorganic elements, essential organic nutrients and other nonessential dietary components. Experimental diets for establishing baseline responses to excess elements should be formulated to meet the animal's requirements only. These reference diets can then be modified to mimic man's average dietary intake as well as meal patterns. Improved animal models should provide better data for assessing hazards of excess metal intake by man.

摘要

近年来，人类因工业污染而普遍接触到越来越多的金属，并且因摄入膳食矿物质补充剂而接触到的金属量也各不相同。其他必需和非必需无机元素、必需有机营养素以及其他非必需膳食成分的膳食水平会显著改变个别金属的不良影响。用于确定对过量元素的基线反应的实验性日粮应仅按满足动物需求来配制。然后可以对这些参考日粮进行调整，以模拟人类的平均膳食摄入量以及用餐模式。改进后的动物模型应能为评估人类过量摄入金属的危害提供更好的数据。