Fox M R, Jacobs R M, Jones A O, Fry B E
Environ Health Perspect. 1979 Feb;28:107-14. doi: 10.1289/ehp.7928107.
Several nutrients are known to affect cadmium toxicity, but little is known about the effect of dietary nutrient levels on absorption and tissue retention of cadmium at low dietary levels, similar to those of man. Feeding gradedlevels of zinc in a casein-gelatin diet to young Japanese quail with 109Cd (as the chloride) and 0.062 ppm added cadmium decreased the cadmium concentrations in the proventriculus-ventriculus, duodenum, jejunum-ileum, and the liver, but not in the kidney. Zinc also affected some zinc, iron, manganese, and copper tissue levels. Different tissue concentration patterns of cadmium and essential minerals were obtained with two purified control diets, one based on casein-gelatin and the other on soy isolate as the principal protein sources. The data show that relatively small dietary changes can markedly affect tissue levels of cadmium and that a low intake of zinc may increase the risk to dietary cadmium exposure. The complexity of the nutrient interrelationships and their effects on cadmium require further study to define mechanisms, which may be similar to those produced by low cadmium intakes in man.
已知几种营养素会影响镉的毒性，但对于与人类相似的低膳食水平下，膳食营养素水平对镉吸收及组织留存的影响却知之甚少。在酪蛋白 - 明胶日粮中给幼龄日本鹌鹑饲喂不同水平的锌，并添加109Cd（以氯化物形式）和0.062 ppm的镉，结果发现腺胃 - 肌胃、十二指肠、空肠 - 回肠及肝脏中的镉浓度降低，但肾脏中的镉浓度未降低。锌还影响了一些锌、铁、锰和铜的组织水平。以酪蛋白 - 明胶和大豆分离蛋白作为主要蛋白质来源的两种纯化对照日粮，得到了镉及必需矿物质不同的组织浓度模式。数据表明，相对较小的膳食变化可显著影响镉的组织水平，低锌摄入量可能会增加膳食镉暴露风险。营养素相互关系的复杂性及其对镉的影响需要进一步研究以确定其机制，这些机制可能与人类低镉摄入量所产生的机制相似。
