Vallyathan N V, Craighead J E
Hum Pathol. 1981 Jan;12(1):28-35. doi: 10.1016/s0046-8177(81)80239-0.
We studied pulmonary tissue from seven men employed in the mining and milling of talc that contained minimal amounts of crystalline silica and asbestiform minerals. The lungs exhibited varying degrees of fibrosis, located either adjacent to the vessels and bronchi or diffusely. Semiquantitative estimations of talc in the lung tissue indicated that the extent of the pulmonary lesions corresponded to its concentration in the tissue. Histopathologic findings were evaluated with regard to duration of occupational exposure and radiographic changes in the chest. In three of the seven workers with exposures of 26, 27, and 27 years chest roentgenographic changes were consistent with pneumoconiosis. The lung tissues from four other patients with exposure histories of four, five, 13, and 19 years exhibited focal and diffuse fibrosis with accumulations of talc, but the chest x-ray films were negative. Crystallographic studies of digestates of lung tissue indicated that the talc contained few mineral impurities. An increase in dust load in the lungs was associated with duration of employment.
我们研究了七名从事滑石粉开采和研磨工作的男性的肺组织，这些滑石粉含有少量结晶二氧化硅和石棉状矿物质。肺部呈现出不同程度的纤维化，要么位于血管和支气管附近，要么呈弥漫性分布。对肺组织中滑石粉的半定量评估表明，肺部病变的程度与其在组织中的浓度相对应。根据职业暴露时间和胸部放射学变化对组织病理学结果进行了评估。在七名暴露时间分别为26年、27年和27年的工人中，有三名工人的胸部X线检查结果符合尘肺病表现。另外四名暴露史分别为4年、5年、13年和19年的患者的肺组织呈现出局灶性和弥漫性纤维化，并伴有滑石粉沉积，但胸部X光片结果为阴性。对肺组织消化产物的晶体学研究表明，滑石粉含有的矿物杂质很少。肺部粉尘负荷的增加与就业时间有关。
