Ring J
Fortschr Med. 1977 Nov 3;95(41):2481-4.
All colloidal volume substitutes carry the risk of anaphylactoid reactions. The general incidence of 0.03% is low; however severe complications can occur. There are differnet pathomechanisms involved in the induction of anaphylactoid reactions after infusion of different colloids. Protein aggregates are of pathogenic importance in human serum albumin incompatibility. The addition of stabilizers to the plasma protein solutions can alter the immunogenicity of the protein molecule. Antibodies of the classes IgG and IgM seem to play a role in severe dextran incompatibility. There was a direct correlation of the intensity of the clinical symptoms with the anti-dextran-antibody titer.
所有胶体容量替代物都有发生类过敏反应的风险。0.03%的总体发生率较低；然而，严重并发症仍可能发生。输注不同胶体后引发类过敏反应涉及不同的病理机制。蛋白质聚集体在人血清白蛋白不相容性中具有致病重要性。向血浆蛋白溶液中添加稳定剂可改变蛋白质分子 的免疫原性。IgG和IgM类抗体似乎在严重的右旋糖酐不相容性中起作用。临床症状的严重程度与抗右旋糖酐抗体滴度直接相关。
