Iosulamide: human tolerance study of a new intravenous cholangiographic drug.

A simple dose-ranging human tolerance study of an experimental intravenous cholangiographic agent (iosulamide) was performed. Doses from 10-40 ml were infused in normal, healthy male volunteers. Bile duct opacification appeared adequate at 30-40 ml doses. With higher doses, a large percentage of the drug was excreted in the urine. Forty percent of the subjects manifested symptoms of minimal or mild contrast reactions.