Fischer H W
Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S148-50. doi: 10.1097/00004424-198011001-00031.
After four score years of alimentary tract radiology based on barium sulfate, we have little agreement on the proper characteristics of the contrast agent for visualization of the esophagus, stomach, duodenum, and colon, nor have we had any viable replacements, organic or inorganic, for barium sulfate. A number of characteristics of barium sulfate preparations have been examined. A positive charge on the particle is not of advantage in mucosal coating, but viscosity seems to be important. Particle size is probably not important. Suspension stability is probably overrated. Much, if not most, of the properties of barium sulfate preparations depend on the surface active agents, the so-called additives. The thickness of barium sulfate coating necessary for surface visualization under clinical conditions is defined. Some preliminary data on a new barium preparation is reported.
在基于硫酸钡的消化道放射学发展了八十多年后，对于用于食管、胃、十二指肠和结肠显影的造影剂的合适特性，我们几乎没有达成共识，而且我们也没有任何可替代硫酸钡的可行物质，无论是有机的还是无机的。人们已经研究了硫酸钡制剂的一些特性。颗粒上带正电荷对粘膜涂层并无益处，但粘度似乎很重要。颗粒大小可能并不重要。悬浮稳定性可能被高估了。硫酸钡制剂的许多特性（如果不是大多数特性的话）取决于表面活性剂，即所谓的添加剂。定义了临床条件下表面显影所需的硫酸钡涂层厚度。报告了一种新型钡制剂的一些初步数据。
