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迷走神经电刺激后的血胃泌素水平(作者译)

[Blood gastrin levels after electrical stimulation of the vagus (author's transl)].

作者信息

Leger L, Souciet C, Chiche B, Ingrand J

出版信息

J Chir (Paris). 1981 Jan;118(1):63-7.

PMID:7204515
Abstract

Acid secretion from the cells bordering the gastric fundus may be stimulated by a direct action of histamine or pentagastrin... or from electrical stimulation of the vagus as used to control vagotomy. It is not known, however, whether this latter effect is due to direct stimulation of the lining cells or follows hypersecretion of gastrin. In order to clarify this point, a stimulus was applied to the isolated vagus during vagotomy, and gastric acid and peripheral blood gastrin levels measured. Increased or decreased gastrin levels were noted in about the same number of cases. No direct relationship with pH variations was observed, and confirmation that vagal stimulation affects the lining cells through the intermediary of increased systemic blood gastrin levels was not obtained.

摘要

胃底周围细胞的胃酸分泌可能受到组胺或五肽胃泌素的直接作用刺激……或者通过用于控制迷走神经切断术的迷走神经电刺激来刺激。然而,尚不清楚后一种效应是由于直接刺激内衬细胞还是由于胃泌素分泌过多所致。为了阐明这一点,在迷走神经切断术中对分离的迷走神经施加刺激,并测量胃酸和外周血胃泌素水平。在大约相同数量的病例中观察到胃泌素水平升高或降低。未观察到与pH变化有直接关系,也未证实迷走神经刺激通过增加全身血胃泌素水平的中介作用影响内衬细胞。

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