13,18 - 脱氢格劳卡鲁宾酮的分离与结构，一种来自苦木科植物苦木的新型抗肿瘤喹啉类化合物。
The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara.
作者信息
Polonsky J, Varon Z, Jacquemin H, Pettit G R
出版信息
Experientia. 1978 Sep 15;34(9):1122-3. doi: 10.1007/BF01922904.
PMID:720499
Abstract
An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2'-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2'-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.
摘要
对圭亚那植物苦木（Simarouba amara Aubl.，苦木科）进行抗肿瘤类苦木素的研究，导致分离并确定了新的类苦木素2'-乙酰基格劳卡鲁宾（1a）和13,18-脱氢格劳卡鲁宾酮（2）的结构。还获得了先前已知的2'-乙酰基格劳卡鲁宾酮（3a）和格劳卡鲁宾酮（3b）。发现新的类苦木素2能显著抑制小鼠淋巴细胞白血病P388的生长。
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