植物抗癌剂。二十三。6α-千里光酰氧基查帕林，一种来自多花锡马巴的新型抗白血病苦木素类化合物。
Plant anticancer agents. XXIII. 6 alpha-senecioyloxychaparrin, a new antileukemic quassinoid from Simaba multiflora.
作者信息
Arisawa M, Kinghorn A D, Cordell G A, Farnsworth N R
出版信息
J Nat Prod. 1983 Mar-Apr;46(2):218-21. doi: 10.1021/np50026a015.
PMID:6875576
Abstract
Fractionation of an aqueous ethanol extract of the wood of Simaba multiflora afforded a new antineoplastic quassinoid, 6 alpha-senecioyloxychaparrin (5), and two known quassinoids 6 alpha-senecioyloxychaparrinone (1) and chaparrinone (2). The structure of 5, which displayed activity against the KB and P-388 test systems, was established through the interpretation of spectral data.
摘要
对多花西马巴木材的乙醇水提取物进行分馏，得到一种新的抗肿瘤苦木素类化合物6α-千里光酰氧基查帕林（5）以及两种已知的苦木素类化合物6α-千里光酰氧基查帕林酮（1）和查帕林酮（2）。通过光谱数据解析确定了具有抗KB和P - 388测试体系活性的化合物5的结构。
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