Polonsky J, Bhatnagar S, Moretti C
J Nat Prod. 1984 Nov-Dec;47(6):994-6. doi: 10.1021/np50036a014.
Investigation of the leaf extract of Picrolemma pseudocoffea afforded a new antineoplastic quassinoid, 15-deacetylsergeolide (3), and two known quassinoids, isobruceine B (1) and sergeolide (2). The structure of 3, which displayed strong antileukemic activity in the P-388 test system, was established through the interpretation of spectral data and chemical correlation to 2.
对拟咖啡苦榄木(Picrolemma pseudocoffea)叶提取物的研究得到了一种新的抗肿瘤苦木素类化合物15-去乙酰基塞尔乔苷(3),以及两种已知的苦木素类化合物异布鲁斯碱B(1)和塞尔乔苷(2)。化合物3在P-388测试系统中表现出很强的抗白血病活性,通过光谱数据解析以及与化合物2的化学关联确定了其结构。