神经肌肉疾病中血清肌红蛋白的放射免疫测定
Radioimmunoassay of serum myoglobin in neuromuscular diseases.
作者信息
Askmark H, Osterman P O, Roxin L E, Venge P
出版信息
J Neurol Neurosurg Psychiatry. 1981 Jan;44(1):68-72. doi: 10.1136/jnnp.44.1.68.
Abstract
Radioimmunoassay of serum myoglobin was performed in 85 patients with muscular symptoms. Elevated levels were found in 93% of patients with myogenic myopathy, in 54% with myasthenia gravis and in 50% with neurogenic myopathy. All 11 patients with polymyositis had elevated myoglobin concentrations. In six of seven patients with polymyositis, who were followed up with repeated determinations, a clear relationship between myoglobin levels and clinical course was found. In general serum myoglobin seemed to be a more sensitive indicator of muscle disease than creatine kinase.
摘要
对85例有肌肉症状的患者进行了血清肌红蛋白的放射免疫测定。在93%的肌源性肌病患者、54%的重症肌无力患者和50%的神经源性肌病患者中发现肌红蛋白水平升高。所有11例多发性肌炎患者的肌红蛋白浓度均升高。在7例接受重复测定随访的多发性肌炎患者中，有6例发现肌红蛋白水平与临床病程之间存在明显关系。一般来说，血清肌红蛋白似乎是比肌酸激酶更敏感的肌肉疾病指标。
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