Alich A A, Wittmers L E
J Pharm Sci. 1980 Jun;69(6):725-7. doi: 10.1002/jps.2600690631.
Hydrolysis rates of acetylsalicylate in the free acid and anion forms and in the dilute solution of the copper complex, tetrakis-mu-acetylsalicylato-dicopper(II), were compared. The hydrolysis rate was unaffected by the presence of copper(II). The pH-dependent rate was 3.64 x 10(-4) mmole/liter/min per pH unit at 37 degrees in Ringer's solution. The synthetic procedures commonly used for the preparation of this compound yield a product contaminated with salicylate. This contamination is avoided by synthesis of the compound in methanol, which yields a complex containing no measurable salicylate.
比较了游离酸和阴离子形式的乙酰水杨酸酯以及铜配合物四-μ-乙酰水杨酸根合二铜（II）稀溶液中的水解速率。铜（II）的存在不影响水解速率。在林格氏溶液中，37℃时pH依赖性速率为每pH单位3.64×10⁻⁴毫摩尔/升/分钟。制备该化合物常用的合成方法会产生被水杨酸酯污染的产物。通过在甲醇中合成该化合物可避免这种污染，甲醇合成法得到的配合物不含可检测到的水杨酸酯。
