Kishore V
College of Pharmacy, Xavier University of Louisiana, New Orleans 70125.
Biol Trace Elem Res. 1990 May;25(2):123-35. doi: 10.1007/BF02990273.
Concentrations of copper, zinc, and iron were analyzed and compared in a number of tissues of adjuvant arthritic rats following 22 d of chronic treatment (per os) with either vehicle, aspirin or copper aspirinate, at doses of 100 mg/kg, 200 mg/kg, or 400 mg/kg. Such chronic treatment resulted in a negative balance in copper, zinc, and iron in many tissues. Among the tissues examined, liver and kidney exhibited the greatest changes in metal concentrations; brain and skeletal muscle exhibited the least. Arthritis-induced changes in the concentrations of all three metals in the liver were reversed upon treatment with aspirin. Treatment with copper aspirinate, on the other hand, resulted in an extremely high accumulation of copper in the liver. Arthritis-induced changes in copper, zinc, and iron concentrations in the pancreas and copper concentration in the plasma were generally not reversed upon treatment with either aspirin or copper aspirinate. Among the three metals examined, the degree of change observed as a result of drug treatments was greatest for iron and least for zinc. Finally, it appeared that the effects of aspirin and copper aspirinate on tissue metal concentrations were independent of the antiarthritic effects of these compounds.
对佐剂性关节炎大鼠的多种组织进行了铜、锌和铁浓度的分析与比较。这些大鼠在经过22天的慢性治疗（经口给药）后，分别给予赋形剂、阿司匹林或阿司匹林铜，剂量为100mg/kg、200mg/kg或400mg/kg。这种慢性治疗导致许多组织中铜、锌和铁出现负平衡。在所检查的组织中，肝脏和肾脏的金属浓度变化最大；大脑和骨骼肌的变化最小。关节炎引起的肝脏中所有三种金属浓度的变化在用阿司匹林治疗后得到逆转。另一方面，用阿司匹林铜治疗导致肝脏中铜的极高积累。关节炎引起的胰腺中铜、锌和铁浓度以及血浆中铜浓度的变化，在用阿司匹林或阿司匹林铜治疗后通常不会逆转。在所检查的三种金属中，药物治疗导致的变化程度对铁最大，对锌最小。最后，阿司匹林和阿司匹林铜对组织金属浓度的影响似乎与这些化合物的抗关节炎作用无关。
