Chapman S K, Glant S K
J Pharm Sci. 1980 Jun;69(6):733-5. doi: 10.1002/jps.2600690635.
The antiproliferative properties of inhibitors of polyamine synthesis were evaluated in cultured neuroblastoma and glioma cells. The diamines (1,3-propanediamine, 1,5-pentanediamine, and 1,6-hexanediamine) dramatically decreased neuroblastoma replication and inhibited the rate-limiting enzyme, ornithine decarboxylase. Glioma cells were less sensitive to the diamines in spite of significant drug-induced decreases in enzyme activity. The fact that ornithine decarboxylase was inhibited in both cell lines with different effects on proliferation suggests that the activity of other enzymes in polyamine biosynthesis may be altered selectively by these inhibitors.
在培养的神经母细胞瘤和胶质瘤细胞中评估了多胺合成抑制剂的抗增殖特性。二胺（1,3 - 丙二胺、1,5 - 戊二胺和1,6 - 己二胺）显著降低神经母细胞瘤的复制，并抑制限速酶鸟氨酸脱羧酶。尽管药物诱导酶活性显著降低，但胶质瘤细胞对二胺的敏感性较低。鸟氨酸脱羧酶在两种细胞系中均受到抑制，但对增殖有不同影响，这表明这些抑制剂可能选择性地改变多胺生物合成中其他酶的活性。
