Chiou G C, Martin M K
J Pharm Sci. 1980 May;69(5):592-4. doi: 10.1002/jps.2600690532.
Neuroblastoma-inoculated A/J mice were treated with various anticancer chemotherapeutic agents, including cyclophosphamide, daunorubicin, vincristine, alpha-bungarotoxin, dihydroxytryptamine, and diaminopropane. Cyclophosphamide and diaminopropane inhibited neuroblastoma as effectively as bromoacetylcholine and bromacetate. The effectiveness of these drugs could be related to the inhibition of ornithine decarboxylase, a rate-limiting enzyme for the synthesis of polyamines.
将神经母细胞瘤接种到A/J小鼠体内，然后用各种抗癌化疗药物进行治疗，这些药物包括环磷酰胺、柔红霉素、长春新碱、α-银环蛇毒素、二羟基色胺和二氨基丙烷。环磷酰胺和二氨基丙烷抑制神经母细胞瘤的效果与溴乙酰胆碱和溴乙酸一样有效。这些药物的有效性可能与抑制鸟氨酸脱羧酶有关，鸟氨酸脱羧酶是多胺合成的限速酶。
