Granat M, Aloni T, Makler A, Dar H
J Reprod Med. 1981 Jan;26(1):52-5.
A 22;22 Robertsonian translocation was diagnosed in a husband whose wife had had six consecutive early spontaneous abortions and no normal progeny. With the new multiple-exposure photography (MEP) technique, an accurate, objective and documentary sperm analysis was performed. No abnormality of the essentially defective, genetically unbalanced sperms could be detected in regard to sperm count, motility, velocity and morphology. The only similar translocation previously reported in a male was associated with azoospermia. Recent literature correlating chromosomal aberrations and reproductive failure in the male is discussed in relation to the reported case. The importance of including the male partner in the cytogenetic investigation of couples with habitual abortion is stressed.
一名男性被诊断出患有22;22罗伯逊易位，其妻子连续六次早期自然流产，未生育正常后代。运用新的多重曝光摄影（MEP）技术，对精子进行了准确、客观且有记录的分析。在精子数量、活力、速度和形态方面，未检测到本质上有缺陷、基因不平衡精子的异常情况。此前报道的唯一一例男性类似易位病例与无精子症有关。结合该病例讨论了近期将染色体畸变与男性生殖失败相关联的文献。强调了在习惯性流产夫妇的细胞遗传学调查中纳入男性伴侣的重要性。
