纳洛酮治疗神经性厌食症：对体重增加和脂肪分解的影响。
Naloxone in the treatment of anorexia nervosa: effect on weight gain and lipolysis.
作者信息
Moore R, Mills I H, Forster A
出版信息
J R Soc Med. 1981 Feb;74(2):129-31. doi: 10.1177/014107688107400208.
Abstract
The effects of a constant intravenous infusion of naloxone in doses ranging from 3.2 to 6.4 mg/day were studied in a group of patients with anorexia nervosa. Patients showed a significantly greater weight gain during the infusion compared with the periods before and after naloxone. Plasma β-hydroxybutyrate and non-esterified fatty acid levels fell during the infusion. It is suggested that, in man, naloxone has an antilipolytic effect in vivo.
摘要
对一组神经性厌食症患者研究了每日静脉输注3.2至6.4毫克剂量纳洛酮的效果。与输注纳洛酮之前和之后的时期相比，患者在输注期间体重显著增加。输注期间血浆β-羟基丁酸酯和非酯化脂肪酸水平下降。提示在人体内，纳洛酮在体内具有抗脂解作用。
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本文引用的文献
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Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
2
Microdetermination of long-chain fatty acids in plasma and tissues.血浆和组织中长链脂肪酸的微量测定
J Biol Chem. 1960 Sep;235:2595-9.
3
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4
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J Physiol. 1977 Oct;271(2):51P-52P.
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