Celozzi E, Lotti V J, Stapley E O, Miller A K
J Pharmacol Methods. 1980 Dec;4(4):285-9. doi: 10.1016/0160-5402(80)90048-0.
The paw-licking response of rats to a subplantar injection of an antibiotic was used as an indicator of the pain caused by that antibiotic. Good agreement with clinical findings was obtained with cefoxitin, cephalothin, cephradine, cefazolin, cephaloridine, and carbenicillin. Incorporation of a local anesthetic into the diluent of an irritating antibiotic reduced the number of paw-licking episodes. This rat paw model offers a simple and rapid means of estimating pain-on-injection following intramuscular injection of antibiotics to humans and may be applicable to other drugs as well.
大鼠对足底注射抗生素的舔爪反应被用作该抗生素所致疼痛的指标。头孢西丁、头孢噻吩、头孢拉定、头孢唑林、头孢匹林和羧苄青霉素的结果与临床发现高度一致。在刺激性抗生素的稀释剂中加入局部麻醉剂可减少舔爪次数。这种大鼠爪模型为评估人类肌肉注射抗生素后的注射疼痛提供了一种简单快速的方法，也可能适用于其他药物。
