Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.

Suppr

超能文献

作者信息

Thakker D R, Yagi H, Akagi H, Koreeda M, Lu A H, Levin W, Wood A W, Conney A H, Jerina D M

出版信息

Chem Biol Interact. 1977 Mar;16(3):281-300. doi: 10.1016/0009-2797(77)90108-9.

DOI:10.1016/0009-2797(77)90108-9

PMID:862130

Abstract

摘要

相似文献

Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.

Chem Biol Interact. 1977 Mar;16(3):281-300. doi: 10.1016/0009-2797(77)90108-9.

Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4'5-epoxide as a metobolite of benzoapyrene.

Arch Biochem Biophys. 1975 May;168(1):322-6. doi: 10.1016/0003-9861(75)90256-8.

Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.

Science. 1977 Jun 10;196(4295):1199-201. doi: 10.1126/science.870975.

Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.

Cancer Res. 1981 Apr;41(4):1389-96.

Effects of a 6-fluoro substituent on the metabolism of benzo(a)pyrene 7,8-dihydrodiol to bay-region diol epoxides by rat liver enzymes.

J Biol Chem. 1984 Sep 25;259(18):11249-56.

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

Proc Natl Acad Sci U S A. 1976 Oct;73(10):3381-5. doi: 10.1073/pnas.73.10.3381.

Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

Cancer Res. 1976 Sep;36(9 pt.1):3358-66.

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

J Biol Chem. 1976 Aug 25;251(16):4882-90.

Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.

Mol Pharmacol. 1981 Jan;19(1):168-78.

Selective fluorescence quenching of benzo[a]pyrene and a mutagenic diol expoxide derivative in mouse cells.

Biochemistry. 1978 Oct 3;17(20):4332-7. doi: 10.1021/bi00613a034.

引用本文的文献

Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage.

Cell Biol Toxicol. 2022 Apr;38(2):291-310. doi: 10.1007/s10565-021-09606-z. Epub 2021 Apr 16.

Quantitative analysis of PAH compounds in DWH crude oil and their effects on Caenorhabditis elegans germ cell apoptosis, associated with CYP450s upregulation.

Sci Total Environ. 2020 Nov 25;745:140639. doi: 10.1016/j.scitotenv.2020.140639. Epub 2020 Jul 1.

Repair-Resistant DNA Lesions.

Chem Res Toxicol. 2017 Aug 21;30(8):1517-1548. doi: 10.1021/acs.chemrestox.7b00128. Epub 2017 Aug 10.

Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.

Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.

Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: absolute configuration and conformation.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1433-8. doi: 10.1073/pnas.0307305101. Epub 2004 Feb 2.

Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12498-503. doi: 10.1073/pnas.2032456100. Epub 2003 Oct 1.

Fungal oxidation of (+/-)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: formation of diastereomeric benzo[a]pyrene 9,10-diol 7,8-epoxides.

Proc Natl Acad Sci U S A. 1980 Aug;77(8):4554-8. doi: 10.1073/pnas.77.8.4554.

Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate.

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5122-6. doi: 10.1073/pnas.79.17.5122.

Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.

Proc Natl Acad Sci U S A. 1981 Feb;78(2):940-2. doi: 10.1073/pnas.78.2.940.

The effect of the bay-region 12-methyl group on the stereoselective metabolism at the K-region of 7,12-dimethylbenz[a]anthracene by rat liver microsomes.

Biochem J. 1984 Nov 1;223(3):775-82. doi: 10.1042/bj2230775.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验