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Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.

作者信息

Thakker D R, Yagi H, Akagi H, Koreeda M, Lu A H, Levin W, Wood A W, Conney A H, Jerina D M

出版信息

Chem Biol Interact. 1977 Mar;16(3):281-300. doi: 10.1016/0009-2797(77)90108-9.

DOI:10.1016/0009-2797(77)90108-9
PMID:862130
Abstract
摘要

相似文献

1
Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.苯并[a]芘的代谢。VI. 苯并[a]芘和苯并[a]芘7,8-二氢二醇向二醇环氧化物的立体选择性代谢。
Chem Biol Interact. 1977 Mar;16(3):281-300. doi: 10.1016/0009-2797(77)90108-9.
2
Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4'5-epoxide as a metobolite of benzoapyrene.通过高压液相色谱法分离并鉴定苯并(a)芘-4'5-环氧化物作为苯并芘的一种代谢产物。
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Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.苯并[a]芘二醇环氧化物：酶促形成机制及光学活性中间体
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4
Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.7,8-苯并黄酮对苯并[e]芘9,10-二氢二醇向湾区二醇环氧化物的肝微粒体代谢的种属特异性增强作用。
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5
Effects of a 6-fluoro substituent on the metabolism of benzo(a)pyrene 7,8-dihydrodiol to bay-region diol epoxides by rat liver enzymes.6-氟取代基对大鼠肝脏酶将苯并(a)芘7,8-二氢二醇代谢为湾区二醇环氧化物的影响。
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6
Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.苯并[a]芘的代谢：（±）-反式-7,8-二羟基-7,8-二氢苯并[a]芘向高致突变性的7,8-二羟基-9,10-环氧化物的转化。
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3381-5. doi: 10.1073/pnas.73.10.3381.
7
Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.苯并(a)芘苯环环氧化物的致突变性和细胞毒性。
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Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.通过高度纯化的肝微粒体酶将苯并(a)芘和苯并(a)芘衍生物代谢为致突变产物。
J Biol Chem. 1976 Aug 25;251(16):4882-90.
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Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.大鼠肝脏酶将屈和菲代谢为湾区二醇环氧化物。
Mol Pharmacol. 1981 Jan;19(1):168-78.
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Selective fluorescence quenching of benzo[a]pyrene and a mutagenic diol expoxide derivative in mouse cells.小鼠细胞中苯并[a]芘和一种致突变二醇环氧化物衍生物的选择性荧光猝灭
Biochemistry. 1978 Oct 3;17(20):4332-7. doi: 10.1021/bi00613a034.

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