小鼠精子和精原细胞中诱导突变率与自发突变率的一些比较。

Some comparisons between induced and spontaneous mutation rates in mouse sperm and spermatogonia.

作者信息

Dunn G R, Kohn H I

出版信息

Mutat Res. 1981 Jan;80(1):159-64. doi: 10.1016/0027-5107(81)90185-8.

PMID:7207480

Abstract

The induction of histocompatibility gene mutations in BALB/cKh mouse sperm was determined following doses of 0, 350, or 350 + 300 rad (24 h apart) of 250 kV X-rays. The mutation rate is significantly lower than predicted on the basis of the seven-locus test and is not significantly different from the very low rate of H-loci in BALB/cKh spermatogonia. Furthermore, selection and repair are important in determining mutation rates per viable progeny of H-loci during both spermatogenesis and gestation.

摘要

在对BALB/cKh小鼠精子进行0、350或350 + 300拉德（间隔24小时）的250 kV X射线照射后，测定了组织相容性基因突变的诱导情况。突变率显著低于基于七基因座测试预测的结果，并且与BALB/cKh精原细胞中H基因座的极低突变率没有显著差异。此外，在精子发生和妊娠期间，选择和修复对于确定H基因座每个存活后代的突变率很重要。