Gambert S R
Neuroendocrinology. 1981 Feb;32(2):114-7. doi: 10.1159/000123141.
These studies investigated the effect of aging on thyroid hormone regulation of beta-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of beta-endorphin declined with age. In addition, age modified the response of beta-endorphin to thyroid hormone status. Hypothyroid rats aged 6 months (mature) exhibited a 67% mean decline in the level of beta-endorphin in the corpus striatum. Hypothyroid rats aged 20-24 months (senescent) exhibited no change in the level of beta-endorphin in the corpus striatum. Hypothyroid rats aged 6 months had a 28% mean decline in the level of hypothalamic beta-endorphin. There was no change in hypothalamic beta-endorphin content in hypothyroid senescent rats. Hyperthyroidism resulted in elevations of beta-endorphin in both the corpus striatum and hypothalamus in senescent, but not mature rats. Changes in beta-endorphin seen with age are at least in part thyroid hormone dependent. In addition, age is capable of modifying the response of brain tissue to thyroid hormone.
这些研究调查了衰老对大鼠纹状体和下丘脑中β-内啡肽甲状腺激素调节的影响。在这两个脑区，β-内啡肽的基础水平均随年龄下降。此外，年龄改变了β-内啡肽对甲状腺激素状态的反应。6个月龄（成熟）的甲状腺功能减退大鼠纹状体中β-内啡肽水平平均下降67%。20 - 24个月龄（衰老）的甲状腺功能减退大鼠纹状体中β-内啡肽水平无变化。6个月龄的甲状腺功能减退大鼠下丘脑β-内啡肽水平平均下降28%。甲状腺功能减退的衰老大鼠下丘脑β-内啡肽含量无变化。甲状腺功能亢进导致衰老大鼠（而非成熟大鼠）的纹状体和下丘脑中β-内啡肽升高。随年龄出现的β-内啡肽变化至少部分依赖于甲状腺激素。此外，年龄能够改变脑组织对甲状腺激素的反应。
