Herzfeld A, Raper S M, Gore I
Pediatr Res. 1980 Dec;14(12):1304-10. doi: 10.1203/00006450-198012000-00006.
Thymidine kinase activities, virtually all soluble in rat lung, liver, and small intestine, decreased abruptly late in gestation or immediately after birth. An injection of thyroxine delayed the fetal but not the neonatal changes in liver activity. An injection of cortisol decreased hepatic and pulmonary thymidine kinase activities in both fetal and neonatal rats but had little effect on the intestinal enzyme. Premature extrauterinization led to an earlier occurrence of the quantitative changes in thymidine kinase activity usually seen at term. Birth-associated changes included a rapid transitory increase in the hepatic enzyme and the virtual loss of intestinal thymidine kinase activity. In human tissues, the soluble thymidine kinase in liver remained high between the 11th and 22nd wk of gestation whereas the particulte enzyme, the predominant form in adult liver, rose in the second half of gestation and reached adult levels at birth. In human lung, the soluble enzyme started to decrease by the 16th gestational wk, whereas the particulate thymidine kinase reached the higher adult levels late in gestation. Thymidine kinase in adult human tissues was predominantly particulate.
胸苷激酶活性在大鼠肺、肝和小肠中几乎全部可溶，在妊娠后期或出生后立即急剧下降。注射甲状腺素可延迟胎儿肝脏活性的变化，但不能延迟新生儿的变化。注射皮质醇可降低胎儿和新生大鼠肝脏和肺中的胸苷激酶活性，但对肠道酶的影响很小。早产导致通常在足月时出现的胸苷激酶活性定量变化提前发生。与出生相关的变化包括肝脏酶的快速短暂增加以及肠道胸苷激酶活性几乎丧失。在人体组织中，肝脏中的可溶性胸苷激酶在妊娠第11周至22周之间保持较高水平，而成人肝脏中主要形式的颗粒酶在妊娠后半期上升并在出生时达到成人水平。在人肺中，可溶性酶在妊娠第16周开始下降，而颗粒胸苷激酶在妊娠后期达到较高的成人水平。成人人体组织中的胸苷激酶主要是颗粒状的。
