Sadava D, Bernard B
Joint Science Department, Claremont Colleges, CA 91711.
Life Sci. 1990;47(25):2359-64. doi: 10.1016/0024-3205(90)90275-v.
The transition from cytosolic ("fetal") to mitochondrial ("adult") thymidine kinase, as detected by electrophoresis, was examined in six human fetal tissues of gestational ages 11-40 weeks. In all tissues there was an early period during development in which only the fetal form was detected, followed by a transitional period in which both fetal and adults forms were present, followed by a later period in which only the adult enzyme occurred. Transitional periods were 23-25 wk. gestational age for colon, 13-15 wk. for kidney, 18-20 wk. for liver, 14-18 wk. for lung, 34-36 wk. for serum, and 25-28 wk. for thyroid. In all cases, only the adult form was present by the time of birth and persisted during the first 18 months of extrauterine life. The adult form, but not the fetal form, was inhibited by dCTP.
通过电泳检测，对孕龄为11 - 40周的六种人类胎儿组织中胞质（“胎儿型”）胸苷激酶向线粒体（“成人型”）胸苷激酶的转变进行了研究。在所有组织的发育过程中，都有一个早期阶段，在此阶段仅检测到胎儿型，随后是一个过渡期，此时胎儿型和成人型都存在，接着是一个后期阶段，此时仅出现成人型酶。结肠的过渡期为孕龄23 - 25周，肾脏为13 - 15周，肝脏为18 - 20周，肺为14 - 18周，血清为34 - 36周，甲状腺为25 - 28周。在所有情况下，出生时仅存在成人型，并在宫外生活的前18个月持续存在。成人型胸苷激酶受dCTP抑制，而胎儿型不受抑制。
