Merkel A D, Wayner M J, Jolicoeur F B, Mintz R
Pharmacol Biochem Behav. 1981 Feb;14(2):235-40. doi: 10.1016/0091-3057(81)90249-5.
The effects of caffeine on food and water intake was assessed in rats maintained under several experimental conditions. In Experiment 1, caffeine, 3.125, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/kg was injected into 23 hr food deprived, 23 hr water deprived or ad lib animals. In Experiment 2, animals were adapted to a 21 hr food deprivation schedule and administered the same doses of caffeine as were used in Experiment 1. Results indicate that caffeine both enhances and decreases food and water intake and that the effects observed depend on the experimental circumstances.
在几种实验条件下饲养的大鼠中评估了咖啡因对食物和水摄入量的影响。在实验1中，将3.125、6.25、12.5、25.0、50.0或100.0mg/kg的咖啡因注射到禁食23小时、禁水23小时或自由进食饮水的动物体内。在实验2中，动物适应21小时的禁食时间表，并给予与实验1相同剂量的咖啡因。结果表明，咖啡因既能增加也能减少食物和水的摄入量，并且观察到的效果取决于实验环境。
