Wayner M J, Jolicoeur F B, Rondeau D B, Barone F C
Pharmacol Biochem Behav. 1976 Sep;5(3):343-8. doi: 10.1016/0091-3057(76)90087-3.
The effects of caffeine (3.125, 6.25, 12.5, 25, 50, and 100 mg/kg) on lever pressing, schedule induced licking and water consumption induced by a fixed interval 1 min schedule were studied. Changes in these dependent variables were assessed when animals were reduced to 80% of their initial body weight by partial food deprivation and when body weights recovered after the animals were returned to conditions of ad lib feeding. Results indicate differential effects of the drug between animals at 80% body weight and when they are permitted to recover. Tolerance was examined for a single large dose only for the same dependent variables in animals at 80% body weight.
研究了咖啡因（3.125、6.25、12.5、25、50和100毫克/千克）对按杆行为、定时诱导舔舐以及由固定间隔1分钟程序诱导的饮水的影响。当动物通过部分禁食使其体重降至初始体重的80%时，以及当动物恢复自由进食体重恢复后，评估这些因变量的变化。结果表明，该药物对体重为80%的动物和体重恢复后的动物有不同的影响。仅对体重为80%的动物中相同的因变量检查了单次大剂量的耐受性。
