Peiker G, Schröder S, Voigt R, Müller B, Nöschel H
Pharmazie. 1980 Dec;35(12):790-3.
Using an open one- and two-compartment model, the authors studied the kinetics of cephalothin during pregnancy and in the course of labour as well as in a group of non-pregnant women. They found that the parenteral application of cephalothin leads to therapeutic levels in the serum, tissues and urine also during pregnancy and in the course of labour. The bearing of pregnancy and labour on the kinetics of cephalothin is but insignificant; consequently, no modification of the pharmacotherapy will be necessary.
作者采用开放的一室和二室模型，研究了头孢噻吩在孕期、分娩过程以及一组非孕女性体内的动力学。他们发现，即使在孕期和分娩过程中，肠胃外使用头孢噻吩也能使血清、组织和尿液达到治疗水平。怀孕和分娩对头孢噻吩动力学的影响微不足道；因此，无需调整药物治疗方案。
