[On the kinetics of pethidine in the late state of pregnancy (author's transl)].

The kinetic of pethidine (Dolcontral) during late pregnancy was investigated by means of an open two-compartment-model. The results were compared with a control group of nonpregnant women. Some pharmakokinetic parameters were found changed during gravidity, especially the distribution (V1, Vdss, Cpo, delta'), the elimination half-life and the biological half-life (t 1/2; ke1, t 1/2; beta). There was no significant difference in urin excretion of pethidin and norpethidin between both groups.