Peiker G, Müller B, Ihn W, Nöschel H, Schade W
Pharmazie. 1981;36(2):124-8.
The kinetic of pethidine (Dolcontral) during late pregnancy was investigated by means of an open two-compartment-model. The results were compared with a control group of nonpregnant women. Some pharmakokinetic parameters were found changed during gravidity, especially the distribution (V1, Vdss, Cpo, delta'), the elimination half-life and the biological half-life (t 1/2; ke1, t 1/2; beta). There was no significant difference in urin excretion of pethidin and norpethidin between both groups.
采用开放二室模型研究了妊娠晚期哌替啶（度冷丁）的动力学。将结果与非妊娠妇女对照组进行比较。发现妊娠期间一些药代动力学参数发生了变化，尤其是分布（V1、Vdss、Cpo、δ'）、消除半衰期和生物半衰期（t 1/2；ke1，t 1/2；β）。两组间哌替啶和去甲哌替啶的尿排泄无显著差异。
